Synergic hypocholesterolaemic effect ofn-3 PUFA and oestrogen by modulation of hepatic cholesterol metabolism in female rats

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Synergic hypocholesterolaemic effect of n-3 PUFA and oestrogen by modulation of hepatic cholesterol metabolism in female rats.

n-3 PUFA such as EPA and DHA as well as oestrogen have been reported to decrease blood levels of cholesterol, but their underlying mechanism is unclear. The purpose of this study was to determine the effects of the combination of n-3 PUFA supplementation and oestrogen injection on hepatic cholesterol metabolism. Rats were fed a modified AIN-93G diet with 0, 1 or 2 % n-3 PUFA (EPA+DHA) relative ...

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ژورنال

عنوان ژورنال: British Journal of Nutrition

سال: 2015

ISSN: 0007-1145,1475-2662

DOI: 10.1017/s0007114515003517